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Long Non-Coding RNAs in Obesity-Induced Cancer.


ABSTRACT: Many mechanisms of obesity-induced cancers have been proposed. However, it remains unclear whether or not long non-coding RNAs (lncRNAs) play any role in obesity-induced cancers. In this article, we briefly discuss the generally accepted hypotheses explaining the mechanisms of obesity-induced cancers, summarize the latest evidence for the expression of a number of well-known cancer-associated lncRNAs in obese subjects, and propose the potential contribution of lncRNAs to obesity-induced cancers. We hope this review can serve as an inspiration to scientists to further explore the regulatory roles of lncRNAs in the development of obesity-induced cancers. Those findings will be fundamental in the development of effective therapeutics or interventions to combat this life-threatening adverse effect of obesity.

SUBMITTER: Yau MY 

PROVIDER: S-EPMC6162378 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Long Non-Coding RNAs in Obesity-Induced Cancer.

Yau Mabel Yin-Chun MY   Xu Lu L   Huang Chien-Ling CL   Wong Chi-Ming CM  

Non-coding RNA 20180828 3


Many mechanisms of obesity-induced cancers have been proposed. However, it remains unclear whether or not long non-coding RNAs (lncRNAs) play any role in obesity-induced cancers. In this article, we briefly discuss the generally accepted hypotheses explaining the mechanisms of obesity-induced cancers, summarize the latest evidence for the expression of a number of well-known cancer-associated lncRNAs in obese subjects, and propose the potential contribution of lncRNAs to obesity-induced cancers.  ...[more]

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