Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki Y
PROVIDER: S-EPMC6162384 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Suzuki Yuta Y Wang Yunhao Y Au Kin Fai KF Morishita Shinichi S
Genes 20180919 9
We address the problem of observing personal diploid methylomes, CpG methylome pairs of homologous chromosomes that are distinguishable with respect to phased heterozygous variants (PHVs), which is challenging due to scarcity of PHVs in personal genomes. Single molecule real-time (SMRT) sequencing is promising as it outputs long reads with CpG methylation information, but a serious concern is whether reliable PHVs are available in erroneous SMRT reads with an error rate of ∼15%. To overcome the ...[more]