Ontology highlight
ABSTRACT:
SUBMITTER: Weniger M
PROVIDER: S-EPMC6162452 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Cancers 20180906 9
Pancreatic ductal adenocarcinoma (PDAC) has an extraordinarily dense fibrotic stroma that impedes tumor perfusion and delivery of anticancer drugs. Since the extracellular matrix (ECM) comprises the bulk of the stroma, it is primarily responsible for the increased interstitial tissue pressure and stiff mechanical properties of the stroma. Besides its mechanical influence, the ECM provides important biochemical and physical cues that promote survival, proliferation, and metastasis. By serving as ...[more]