Ontology highlight
ABSTRACT:
SUBMITTER: Alvarez-Teijeiro S
PROVIDER: S-EPMC6162704 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Álvarez-Teijeiro Saúl S García-Inclán Cristina C Villaronga M Ángeles MÁ Casado Pedro P Hermida-Prado Francisco F Granda-Díaz Rocío R Rodrigo Juan P JP Calvo Fernando F Del-Río-Ibisate Nagore N Gandarillas Alberto A Morís Francisco F Hermsen Mario M Cutillas Pedro P García-Pedrero Juana M JM
Cancers 20180917 9
This study investigates for the first time the crosstalk between stromal fibroblasts and cancer stem cell (CSC) biology in head and neck squamous cell carcinomas (HNSCC), with the ultimate goal of identifying effective therapeutic targets. The effects of conditioned media from cancer-associated fibroblasts (CAFs) and normal fibroblasts (NFs) on the CSC phenotype were assessed by combining functional and expression analyses in HNSCC-derived cell lines. Further characterization of CAFs and NFs sec ...[more]