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Impaired glucose metabolism is associated with increased thrombin generation potential in patients undergoing angioplasty and stenting.


ABSTRACT: BACKGROUND:As a strong platelet agonist on the one hand and key molecule in plasmatic coagulation on the other hand, thrombin connects primary and secondary hemostasis. Thrombin generation potential reflects the individual capacity to generate thrombin, and has been associated with the occurrence of thromboembolic events. In the current study, we sought to identify predictors of thrombin generation potential in patients undergoing angioplasty and stenting for atherosclerotic cardiovascular disease. METHODS:Peak thrombin generation potential and area under the curve (AUC) of thrombin generation potential were determined with a commercially available assay in 315 patients on dual antiplatelet therapy 1 day after percutaneous intervention, and in 100 healthy individuals without cardiovascular disease. RESULTS:Median (interquartile range) peak thrombin generation potential and AUC of thrombin generation potential in the study cohort (n?=?315) were significantly higher than in healthy individuals (n?=?100) without cardiovascular disease (peak thrombin generation potential: 445.4 nM [354.5-551.8 nM] vs. 174.5 nM [141.2-261.2 nM]; AUC of thrombin generation potential: 5262.7 nM thrombin [4806.6-5756.9 nM thrombin] vs. 3405.2 nM thrombin [3043.6-3747.3 nM thrombin]; both p?

SUBMITTER: Lee S 

PROVIDER: S-EPMC6162876 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Impaired glucose metabolism is associated with increased thrombin generation potential in patients undergoing angioplasty and stenting.

Lee Silvia S   Ay Cihan C   Kopp Christoph W CW   Panzer Simon S   Gremmel Thomas T  

Cardiovascular diabetology 20180929 1


<h4>Background</h4>As a strong platelet agonist on the one hand and key molecule in plasmatic coagulation on the other hand, thrombin connects primary and secondary hemostasis. Thrombin generation potential reflects the individual capacity to generate thrombin, and has been associated with the occurrence of thromboembolic events. In the current study, we sought to identify predictors of thrombin generation potential in patients undergoing angioplasty and stenting for atherosclerotic cardiovascul  ...[more]

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