Pharmaceutical solvate formation for the incorporation of the antimicrobial agent hydrogen peroxide.
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ABSTRACT:
SUBMITTER: Kersten KM
PROVIDER: S-EPMC6163058 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Pharmaceutical solvate formation for the incorporation of the antimicrobial agent hydrogen peroxide.
Kersten Kortney M KM Breen Meghan E ME Mapp Anna K AK Matzger Adam J AJ
Chemical communications (Cambridge, England) 20180801 67
Antimicrobial functionality is introduced into a pharmaceutical formulation of miconazole while improving solubility. The work leverages hydrate formation propensity in order to produce hydrogen peroxide solvates. The ubiquity of hydrate formation suggests that hydrogen peroxide can be broadly deployed in pharmaceuticals, rendering a liquid excipient suitable for solid pharmaceutical formulations. ...[more]
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