Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets.
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ABSTRACT:
SUBMITTER: Sabol M
PROVIDER: S-EPMC6163343 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
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Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets.
Sabol Maja M Trnski Diana D Musani Vesna V Ozretić Petar P Levanat Sonja S
International journal of molecular sciences 20180829 9
GLI transcription factors have important roles in intracellular signaling cascade, acting as the main mediators of the HH-GLI signaling pathway. This is one of the major developmental pathways, regulated both canonically and non-canonically. Deregulation of the pathway during development leads to a number of developmental malformations, depending on the deregulated pathway component. The HH-GLI pathway is mostly inactive in the adult organism but retains its function in stem cells. Aberrant acti ...[more]
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