Dataset Information

Anticancer Effects of Green Tea and the Underlying Molecular Mechanisms in Bladder Cancer.

ABSTRACT: Green tea and green tea polyphenols (GTPs) are reported to inhibit carcinogenesis and malignant behavior in several diseases. Various in vivo and in vitro studies have shown that GTPs suppress the incidence and development of bladder cancer. However, at present, opinions concerning the anticancer effects and preventive role of green tea are conflicting. In addition, the detailed molecular mechanisms underlying the anticancer effects of green tea in bladder cancer remain unclear, as these effects are regulated by several cancer-related factors. A detailed understanding of the pathological roles and regulatory mechanisms at the molecular level is necessary for advancing treatment strategies based on green tea consumption for patients with bladder cancer. In this review, we discuss the anticancer effects of GTPs on the basis of data presented in in vitro studies in bladder cancer cell lines and in vivo studies using animal models, as well as new treatment strategies for patients with bladder cancer, based on green tea consumption. Finally, on the basis of the accumulated data and the main findings, we discuss the potential usefulness of green tea as an antibladder cancer agent and the future direction of green tea-based treatment strategies for these patients.

SUBMITTER: Miyata Y

PROVIDER: S-EPMC6164790 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Anticancer Effects of Green Tea and the Underlying Molecular Mechanisms in Bladder Cancer.

Miyata Yasuyoshi Y Matsuo Tomohiro T Araki Kyohei K Nakamura Yuichiro Y Sagara Yuji Y Ohba Kojiro K Sakai Hideki H

Medicines (Basel, Switzerland) 20180810 3

Green tea and green tea polyphenols (GTPs) are reported to inhibit carcinogenesis and malignant behavior in several diseases. Various in vivo and in vitro studies have shown that GTPs suppress the incidence and development of bladder cancer. However, at present, opinions concerning the anticancer effects and preventive role of green tea are conflicting. In addition, the detailed molecular mechanisms underlying the anticancer effects of green tea in bladder cancer remain unclear, as these effects ...[more]

PMID: 30103466

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Project description:Red and blue light are traditionally believed to have a higher quantum yield of CO2 assimilation (QY, moles of CO2 assimilated per mole of photons) than green light, because green light is absorbed less efficiently. However, because of its lower absorptance, green light can penetrate deeper and excite chlorophyll deeper in leaves. We hypothesized that, at high photosynthetic photon flux density (PPFD), green light may achieve higher QY and net CO2 assimilation rate (A n) than red or blue light, because of its more uniform absorption throughtout leaves. To test the interactive effects of PPFD and light spectrum on photosynthesis, we measured leaf A n of "Green Tower" lettuce (Lactuca sativa) under red, blue, and green light, and combinations of those at PPFDs from 30 to 1,300 μmol⋅m-2⋅s-1. The electron transport rates (J) and the maximum Rubisco carboxylation rate (V c,max) at low (200 μmol⋅m-2⋅s-1) and high PPFD (1,000 μmol⋅m-2⋅s-1) were estimated from photosynthetic CO2 response curves. Both QY m,inc (maximum QY on incident PPFD basis) and J at low PPFD were higher under red light than under blue and green light. Factoring in light absorption, QY m,abs (the maximum QY on absorbed PPFD basis) under green and red light were both higher than under blue light, indicating that the low QY m,inc under green light was due to lower absorptance, while absorbed blue photons were used inherently least efficiently. At high PPFD, the QY inc [gross CO2 assimilation (A g)/incident PPFD] and J under red and green light were similar, and higher than under blue light, confirming our hypothesis. V c,max may not limit photosynthesis at a PPFD of 200 μmol m-2 s-1 and was largely unaffected by light spectrum at 1,000 μmol⋅m-2⋅s-1. A g and J under different spectra were positively correlated, suggesting that the interactive effect between light spectrum and PPFD on photosynthesis was due to effects on J. No interaction between the three colors of light was detected. In summary, at low PPFD, green light had the lowest photosynthetic efficiency because of its low absorptance. Contrary, at high PPFD, QY inc under green light was among the highest, likely resulting from more uniform distribution of green light in leaves.

Dataset Information

Anticancer Effects of Green Tea and the Underlying Molecular Mechanisms in Bladder Cancer.

Publications

Anticancer Effects of Green Tea and the Underlying Molecular Mechanisms in Bladder Cancer.

Similar Datasets

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