Targeting TGF-? Signaling in Kidney Fibrosis.
Ontology highlight
ABSTRACT:
SUBMITTER: Isaka Y
PROVIDER: S-EPMC6165001 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Targeting TGF-β Signaling in Kidney Fibrosis.
International journal of molecular sciences 20180827 9
Renal fibrosis is the final common pathway of numerous progressive kidney diseases, and transforming growth factor-β (TGF-β) has an important role in tissue fibrosis by up-regulating matrix protein synthesis, inhibiting matrix degradation, and altering cell-cell interaction. Many strategies targeting TGF-β, including inhibition of production, activation, binding to the receptor, and intracellular signaling, have been developed. Some of them were examined in clinical studies against kidney fibros ...[more]
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