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Gold Rod-Polyethylene Glycol-Carbon Dot Nanohybrids as Phototheranostic Probes.

ABSTRACT: Emphasis using phototheranostics has been placed on the construction of multifunctional nanoplatforms for simultaneous tumor diagnosis and therapy. Herein, we put forth a novel nanosized luminescent material using the incorporation of red emissive carbon dots on gold nanorods through polyethylene glycol as a covalent linkage for dual-modal imaging and photothermal therapy. The novel nanohybrids, not only retain the optical properties of the gold nanorod and carbon dots, but also possess superior imaging performance in both confocal laser scanning microscopy and fluorescence lifetime imaging microscopy. The nanohybrids also exhibit excellent photothermal performance as phototheranostic nanohybrid probes for in vitro assays. This study promises a new multifunctional nanoplatform for cancer diagnostics and therapeutics.

SUBMITTER: Niu Y

PROVIDER: S-EPMC6165167 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Gold Rod-Polyethylene Glycol-Carbon Dot Nanohybrids as Phototheranostic Probes.

Niu Yuefang Y Ling Guo G Wang Li L Guan Shanyue S Xie Zheng Z Barnoy Eran A EA Zhou Shuyun S Fixler Dror D

Nanomaterials (Basel, Switzerland) 20180910 9

Emphasis using phototheranostics has been placed on the construction of multifunctional nanoplatforms for simultaneous tumor diagnosis and therapy. Herein, we put forth a novel nanosized luminescent material using the incorporation of red emissive carbon dots on gold nanorods through polyethylene glycol as a covalent linkage for dual-modal imaging and photothermal therapy. The novel nanohybrids, not only retain the optical properties of the gold nanorod and carbon dots, but also possess superior ...[more]

PMID: 30201913

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