Ontology highlight
ABSTRACT:
SUBMITTER: Roberts BS
PROVIDER: S-EPMC6166125 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Roberts Benjamin S BS Babilonia-Rosa Melissa A MA Broadwell Lindsey J LJ Wu Ming Jing MJ Neher Saskia B SB
The EMBO journal 20180801 19
Lipoprotein lipase (LPL) is a secreted lipase that clears triglycerides from the blood. Proper LPL folding and exit from the endoplasmic reticulum (ER) require lipase maturation factor 1 (LMF1), an ER-resident transmembrane protein, but the mechanism involved is unknown. We used proteomics to identify LMF1-binding partners necessary for LPL secretion in HEK293 cells and found these to include oxidoreductases and lectin chaperones, suggesting that LMF1 facilitates the formation of LPL's five disu ...[more]