Improved Admixture Vaccine of Fentanyl and Heroin Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated Heroin.
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ABSTRACT:
SUBMITTER: Hwang CS
PROVIDER: S-EPMC6166218 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Improved Admixture Vaccine of Fentanyl and Heroin Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated Heroin.
Hwang Candy S CS Smith Lauren C LC Natori Yoshihiro Y Ellis Beverly B Zhou Bin B Janda Kim D KD
ACS omega 20180920 9
Fentanyl and its derivatives have become pervasive contaminants in the U.S. heroin supply. Previously, we reported a proof-of-concept vaccine designed to combat against heroin contaminated with fentanyl. Herein, we optimized the admixture vaccine and found that it surpassed the individual vaccines in every antinociceptive test, including a 10% fentanyl to heroin formulation. It is anticipated that other co-occurring drug abuse disorders may also be examined with admixture vaccines. ...[more]
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