Inferring Metabolic Mechanisms of Interaction within a Defined Gut Microbiota.
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ABSTRACT:
SUBMITTER: Medlock GL
PROVIDER: S-EPMC6166237 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Inferring Metabolic Mechanisms of Interaction within a Defined Gut Microbiota.
Medlock Gregory L GL Carey Maureen A MA McDuffie Dennis G DG Mundy Michael B MB Giallourou Natasa N Swann Jonathan R JR Kolling Glynis L GL Papin Jason A JA
Cell systems 20180905 3
The diversity and number of species present within microbial communities create the potential for a multitude of interspecies metabolic interactions. Here, we develop, apply, and experimentally test a framework for inferring metabolic mechanisms associated with interspecies interactions. We perform pairwise growth and metabolome profiling of co-cultures of strains from a model mouse microbiota. We then apply our framework to dissect emergent metabolic behaviors that occur in co-culture. Based on ...[more]
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