Ontology highlight
ABSTRACT:
SUBMITTER: Aguado LC
PROVIDER: S-EPMC6166822 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Aguado Lauren C LC Jordan Tristan X TX Hsieh Emily E Blanco-Melo Daniel D Heard John J Panis Maryline M Vignuzzi Marco M tenOever Benjamin R BR
Proceedings of the National Academy of Sciences of the United States of America 20180912 39
RNA interference (RNAi) is the major antiviral defense mechanism of plants and invertebrates, rendering the capacity to evade it a defining factor in shaping the viral landscape. Here we sought to determine whether different virus replication strategies provided any inherent capacity to evade RNAi in the absence of an antagonist. Through the exploitation of host microRNAs, we recreated an RNAi-like environment in vertebrates and directly compared the capacity of positive- and negative-stranded R ...[more]