Unknown

Dataset Information

0

Successful Treatment of Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar Status in an Infant with KCNJ11-Related Neonatal Diabetes Mellitus via Continuous Renal Replacement Therapy.


ABSTRACT: Neonatal diabetes mellitus (NDM) is a rare monogenic disorder presenting as uncontrolled hyperglycemia during the first 6 months of life. Hyperglycemic hyperosmolar state (HHS) is quite rare in NDM patients, and reported experience with this condition is limited. Continuous renal replacement therapy (CRRT) is frequently used as a mode of dialytic treatment in critically ill patients with acute renal failure, but has seldom been used in patients with diabetic ketoacidosis (DKA) and HHS. We report the case of a 2-month-old infant admitted to our hospital presenting with dyspnea and lethargy. Blood gas showed severe hyperosmotic DKA. After 21 h of fluid and insulin therapy, the baby presented with increased drowsiness and irregular respiration, which suggested cerebral edema. Moreover, the DKA and HHS were exacerbated. After 18 h of CRRT, the patient gradually recovered from DKA and HHS. The gene analysis revealed a de novo mutation (c.602G > A (p.R201H)) of the KCNJ11 gene, and oral glibenclamide successfully replaced insulin treatment in the patient.

SUBMITTER: Chen T 

PROVIDER: S-EPMC6167281 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC9846077 | biostudies-literature
| S-EPMC6971788 | biostudies-literature
| S-EPMC7477511 | biostudies-literature
| S-EPMC7611849 | biostudies-literature
| S-EPMC11320749 | biostudies-literature
| S-EPMC4869695 | biostudies-literature
| S-EPMC5493463 | biostudies-other
| S-EPMC9893891 | biostudies-literature
| S-EPMC9508574 | biostudies-literature
| S-EPMC5031218 | biostudies-literature