Ontology highlight
ABSTRACT:
SUBMITTER: Tome-Garcia J
PROVIDER: S-EPMC6167382 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Tome-Garcia Jessica J Erfani Parsa P Nudelman German G Tsankov Alexander M AM Katsyv Igor I Tejero Rut R Bin Zhang Walsh Martin M Friedel Roland H RH Zaslavsky Elena E Tsankova Nadejda M NM
Nature communications 20181001 1
The intrinsic drivers of migration in glioblastoma (GBM) are poorly understood. To better capture the native molecular imprint of GBM and its developmental context, here we isolate human stem cell populations from GBM (GSC) and germinal matrix tissues and map their chromatin accessibility via ATAC-seq. We uncover two distinct regulatory GSC signatures, a developmentally shared/proliferative and a tumor-specific/migratory one in which TEAD1/4 motifs are uniquely overrepresented. Using ChIP-PCR, w ...[more]