Ontology highlight
ABSTRACT:
SUBMITTER: Berkel S
PROVIDER: S-EPMC6167484 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Berkel Simone S Eltokhi Ahmed A Fröhlich Henning H Porras-Gonzalez Diana D Rafiullah Rafiullah R Sprengel Rolf R Rappold Gudrun A GA
Frontiers in molecular neuroscience 20180925
Autism spectrum disorders (ASD) have a higher prevalence in male individuals compared to females, with a ratio of affected boys compared to girls of 4:1 for ASD and 11:1 for Asperger syndrome. Mutations in the <i>SHANK</i> genes (comprising <i>SHANK1</i>, <i>SHANK2</i> and <i>SHANK3</i>) coding for postsynaptic scaffolding proteins have been tightly associated with ASD. As early brain development is strongly influenced by sex hormones, we investigated the effect of dihydrotestosterone (DHT) and ...[more]