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Development of shellfish allergy after exposure to dual immune checkpoint blockade.

ABSTRACT: Hepatocellular carcinoma (HCC) is a major health problem worldwide with limited systemic therapies available. Immunotherapy is a fast-moving field that is quickly evolving as a treatment for HCC with three recent clinical trials published treating HCC with immune checkpoint inhibitors with promising results. Checkpoint inhibition may lead to a unique adverse event profile with the potential to cause immune-related adverse events by unbalancing the immune system. Here, we report a case of a 61-year-old male with advanced HCC who developed a shellfish allergy after completing three cycles of combination of tremelimumab and durvalumab therapy.

SUBMITTER: Brown ZJ

PROVIDER: S-EPMC6168040 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Development of shellfish allergy after exposure to dual immune checkpoint blockade.

Brown Zachary J ZJ Heinrich Bernd B Greten Tim F TF

Hepatic oncology 20180101 1

Hepatocellular carcinoma (HCC) is a major health problem worldwide with limited systemic therapies available. Immunotherapy is a fast-moving field that is quickly evolving as a treatment for HCC with three recent clinical trials published treating HCC with immune checkpoint inhibitors with promising results. Checkpoint inhibition may lead to a unique adverse event profile with the potential to cause immune-related adverse events by unbalancing the immune system. Here, we report a case of a 61-ye ...[more]

PMID: 30302193

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