Efficient two-stage designs and proper inference for animal studies.

ABSTRACT: Cost-effective yet efficient designs are critical to the success of animal studies. We propose a two-stage design for cost-effectiveness animal studies with continuous outcomes. Given the data from the two-stage design, we derive the exact distribution of the test statistic under null hypothesis to appropriately adjust for the design's adaptiveness. We further generalize the design and inferential procedure to the K-sample case with multiple comparison adjustment. We conduct simulation studies to evaluate the small sample behavior of the proposed design and test procedure. The results indicate that the proposed test procedure controls the type I error rate for the one-sample design and the family-wise error rate for K-sample design very well; whereas the naive approach that i

SUBMITTER: Cai C 

PROVIDER: S-EPMC6168085 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature