Efficient two-stage designs and proper inference for animal studies.
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ABSTRACT:
SUBMITTER: Cai C
PROVIDER: S-EPMC6168085 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Efficient two-stage designs and proper inference for animal studies.
Cai Chunyan C Piao Jin J Ning Jing J Huang Xuelin X
Statistics in biosciences 20171213 1
Cost-effective yet efficient designs are critical to the success of animal studies. We propose a two-stage design for cost-effectiveness animal studies with continuous outcomes. Given the data from the two-stage design, we derive the exact distribution of the test statistic under null hypothesis to appropriately adjust for the design's adaptiveness. We further generalize the design and inferential procedure to the <i>K</i>-sample case with multiple comparison adjustment. We conduct simulation st ...[more]
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