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Enhanced neutralizing antibody response induced by inactivated enterovirus 71 in cynomolgus monkeys.


ABSTRACT: Enterovirus 71 (EV71) is a major etiological agent of various public health issues, particularly in the Asia-Pacific region. EV71 causes hand-foot-and-mouth disease (HFMD) and is associated with serious neurological disorders in young children. A formalin-inactivated EV71 candidate vaccine (KCDC-HFMDV1-EV71) based on the C4 subgenotype was previously developed and confirmed to be a potential candidate vaccine for prevention of EV71 infection in mice. In this study, an inactivated EV71 vaccine was used for analysis of long-term immunogenicity and efficacy in cynomolgus monkeys, a common nonhuman primate model. The vaccine was immunized three times at 0, 4, and 8 weeks with either 20-?g doses of EV71 candidate vaccine formulated with aluminum hydroxide gel adjuvant or phosphate-buffered saline as a control. The group immunized with the inactivated EV71 showed significantly increased EV71-specific antibody and serum neutralizing antibody titers at 3 weeks after vaccination and maintained these elevated titers until the end of the experiment (54 weeks after vaccination). The sera from vaccinated cynomolgus monkeys showed a crossreactive neutralizing antibody response to the heterologous subtype of EV71 (B1-4, C1, and C2). These findings suggest that the inactivated EV71 candidate vaccine may be a potential vaccine candidate and valuable tool for the control of HFMD.

SUBMITTER: In HJ 

PROVIDER: S-EPMC6168120 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Enhanced neutralizing antibody response induced by inactivated enterovirus 71 in cynomolgus monkeys.

In Hyun Ju HJ   Lim Heeji H   Lee Jung-Ah JA   Lee Sang-Rae SR   Jin Yeung Bae YB   Jeong Kang-Jin KJ   Hyeon Ji-Yeon JY   Yoo Jung Sik JS   Lee June-Woo JW   Choi Young Ki YK   Lee Sang-Won SW  

PloS one 20181002 10


Enterovirus 71 (EV71) is a major etiological agent of various public health issues, particularly in the Asia-Pacific region. EV71 causes hand-foot-and-mouth disease (HFMD) and is associated with serious neurological disorders in young children. A formalin-inactivated EV71 candidate vaccine (KCDC-HFMDV1-EV71) based on the C4 subgenotype was previously developed and confirmed to be a potential candidate vaccine for prevention of EV71 infection in mice. In this study, an inactivated EV71 vaccine wa  ...[more]

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