Ontology highlight
ABSTRACT:
SUBMITTER: Inoue T
PROVIDER: S-EPMC6168257 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Inoue Takamasa T Zhang Pengwei P Zhang Wei W Goodner-Bingham Kylia K Dupzyk Allison A DiMaio Daniel D Tsai Billy B
The Journal of cell biology 20180713 10
Despite their importance as human pathogens, entry of human papillomaviruses (HPVs) into cells is poorly understood. The transmembrane protease γ-secretase executes a crucial function during the early stages of HPV infection, but the role of γ-secretase in infection and the identity of its critical substrate are unknown. Here we demonstrate that γ-secretase harbors a previously uncharacterized chaperone function, promoting low pH-dependent insertion of the HPV L2 capsid protein into endosomal me ...[more]