An essential Staphylococcus aureus cell division protein directly regulates FtsZ dynamics.
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ABSTRACT:
SUBMITTER: Eswara PJ
PROVIDER: S-EPMC6168285 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
An essential <i>Staphylococcus aureus</i> cell division protein directly regulates FtsZ dynamics.
Eswara Prahathees J PJ Brzozowski Robert S RS Viola Marissa G MG Graham Gianni G Spanoudis Catherine C Trebino Catherine C Jha Jyoti J Aubee Joseph I JI Thompson Karl M KM Camberg Jodi L JL Ramamurthi Kumaran S KS
eLife 20181002
Binary fission has been well studied in rod-shaped bacteria, but the mechanisms underlying cell division in spherical bacteria are poorly understood. Rod-shaped bacteria harbor regulatory proteins that place and remodel the division machinery during cytokinesis. In the spherical human pathogen <i>Staphylococcus aureus</i>, we found that the essential protein GpsB localizes to mid-cell during cell division and co-constricts with the division machinery. Depletion of GpsB arrested cell division and ...[more]
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