Ontology highlight
ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC6168416 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Wang Zhijie Z Yu Gang G Liu Yinan Y Liu Shiyong S Aridor Meir M Huang Yuan Y Hu Yushuang Y Wang Longfei L Li Sisi S Xiong Hongbo H Tang Bo B Li Xia X Cheng Chen C Chakrabarti Susmita S Wang Fan F Wu Qingyu Q Karnik Sadashiva S SS Xu Chengqi C Chen Qiuyun Q Wang Qing K QK
Biochimica et biophysica acta. Molecular basis of disease 20180906 11
<h4>Background</h4>The cardiac sodium channel Na<sub>v</sub>1.5 is essential for the physiological function of the heart and causes cardiac arrhythmias and sudden death when mutated. Many disease-causing mutations in Na<sub>v</sub>1.5 cause defects in protein trafficking, a cellular process critical to the targeting of Na<sub>v</sub>1.5 to cell surface. However, the molecular mechanisms underlying the trafficking of Na<sub>v</sub>1.5, in particular, the exit from the endoplasmic reticulum (ER) f ...[more]