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Histone methyltransferase KMT2D sustains prostate carcinogenesis and metastasis via epigenetically activating LIFR and KLF4.

ABSTRACT: Abnormalities in epigenetic modifiers are emerging as driving events in prostate cancer (PCa). The histone methyltransferase KMT2D, a frequently aberrant epigenetic modifier in various tumors, has an undefined role in PCa. Moreover, little is known regarding KMT2D's mutation in Chinese patients or its downstream signaling pathways and targets. Here, we profiled the mutational spectrum of 32 significantly PCa-associated genes by using disease-targeted sequencing, and found that KMT2D was highly mutated (63.04%, 29/46) in Chinese patients. Moreover, high KMT2D transcription was also associated with poor prognosis in an independent cohort (n?=?51). In KMT2D-knockdown PC-3 and DU145 cells, cell proliferation (P?

SUBMITTER: Lv S

PROVIDER: S-EPMC6168472 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Histone methyltransferase KMT2D sustains prostate carcinogenesis and metastasis via epigenetically activating LIFR and KLF4.

Lv Shidong S Ji Liyan L Chen Bin B Liu Shuqiang S Lei Chengyong C Liu Xi X Qi Xiaoxiao X Wang Ying Y Lai-Han Leung Elaine E Wang Hongyi H Zhang Lin L Yu Xiaoming X Liu Zhongqiu Z Wei Qiang Q Lu Linlin L

Oncogene 20171222 10

Abnormalities in epigenetic modifiers are emerging as driving events in prostate cancer (PCa). The histone methyltransferase KMT2D, a frequently aberrant epigenetic modifier in various tumors, has an undefined role in PCa. Moreover, little is known regarding KMT2D's mutation in Chinese patients or its downstream signaling pathways and targets. Here, we profiled the mutational spectrum of 32 significantly PCa-associated genes by using disease-targeted sequencing, and found that KMT2D was highly m ...[more]

PMID: 29269867

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Histone methyltransferase KMT2D mediated lipid metabolism via peroxisome proliferator-activated receptor gamma in prostate cancer.

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Expression Analysis and Mutational Status of Histone Methyltransferase KMT2D at Different Upper Tract Urothelial Carcinoma Locations.

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The histone methyltransferase KMT2D is essential for embryo implantation via regulating precise differentiation of endometrial cells.

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