Computerised Dynamic Posturography in Premanifest and Manifest individuals with Huntington's Disease.

ABSTRACT: Evidence from small-scale studies indicates that impairments in postural stability are an early and disabling feature of Huntington's disease (HD) and may be a useful clinical endpoint for disease modifying trials. Larger studies are needed to confirm these preliminary findings and the suitability of postural stability outcomes as clinical endpoints. Static and dynamic postural stability were evaluated in 54 premanifest HD, 36 manifest HD and 45 healthy individuals using the Sensory Organization Test (SOT) and Limits of Stability (LOS) test. Manifest HD displayed significantly lower scores on all SOT conditions and on the SOT composite score and had more falls than healthy and premanifest HD (p?

SUBMITTER: Reyes A 

PROVIDER: S-EPMC6168504 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature