Ontology highlight
ABSTRACT:
SUBMITTER: Tan R
PROVIDER: S-EPMC6168561 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Tan Rumeng R Tian Hongzhe H Yang Bo B Zhang Bo B Dai Chen C Han Zhenyi Z Wang Meixi M Li Yakun Y Wei Lai L Chen Dong D Wang Guangyao G Yang Huifang H He Fan F Chen Zhishui Z
Scientific reports 20181002 1
Helix B surface peptide (HBSP) is an erythropoietin (EPO)-derived peptide that protects tissue from the risks of elevated blood pressure and thrombosis. This study focused on the protection of HBSP in hepatic ischaemia/reperfusion (I/R) by enhancing the level of autophagy. In detail, we randomly divided C57BL/6 mice into sham-operated, hepatic ischaemia/reperfusion (I/R), I/R + HBSP, I/R + HBSP + 3-methyladenine (autophagy inhibitor), I/R + HBSP + rapamycin (mTOR inhibitor), and I/R + HBSP + Ly2 ...[more]