Ontology highlight
ABSTRACT:
SUBMITTER: Jackson J
PROVIDER: S-EPMC6168643 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Jackson Jesse J Karnani Mahesh M MM Zemelman Boris V BV Burdakov Denis D Lee Albert K AK
Neuron 20180816 5
The claustrum is a small subcortical nucleus that has extensive excitatory connections with many cortical areas. While the anatomical connectivity from the claustrum to the cortex has been studied intensively, the physiological effect and underlying circuit mechanisms of claustrocortical communication remain elusive. Here we show that the claustrum provides strong, widespread, and long-lasting feedforward inhibition of the prefrontal cortex (PFC) sufficient to silence ongoing neural activity. Th ...[more]