Ontology highlight
ABSTRACT:
SUBMITTER: Wu N
PROVIDER: S-EPMC6168967 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Wu Nan N Meng Fanyin F Zhou Tianhao T Venter Julie J Giang Thao K TK Kyritsi Konstantina K Wu Chaodong C Alvaro Domenico D Onori Paolo P Mancinelli Romina R Gaudio Eugenio E Francis Heather H Alpini Gianfranco G Glaser Shannon S Franchitto Antonio A
The American journal of pathology 20180721 10
Activation of the secretin (Sct)/secretin receptor (SR) axis stimulates ductular reaction and liver fibrosis, which are hallmarks of cholangiopathies. Our aim was to define the role of Sct-regulated cellular senescence, and we demonstrated that both ductular reaction and liver fibrosis are significantly reduced in Sct<sup>-/-</sup>, SR<sup>-/-</sup>, and Sct<sup>-/-</sup>/SR<sup>-/-</sup> bile duct ligated (BDL) mice compared with BDL wild-type mice. The reduction in hepatic fibrosis in Sct<sup> ...[more]