Exosome-transmitted long non-coding RNA PTENP1 suppresses bladder cancer progression.

ABSTRACT:

Background

Extracellular communication within the tumor microenvironment plays a critical role in tumor progression. Although exosomes can package into long non-coding RNAs (lncRNAs) to mediate extracellular communication, the role of exosomal lncRNA PTENP1 in bladder cancer (BC) remains unclear.

Method

We detected PTENP1 expression between patients with BC and healthy controls; the expression occurred in tissues and exosomes from plasma. We assessed the diagnostic accuracy by the receiver operating characteristic curve (ROC) and the area under curve (AUC). Cell phenotypes and animal experiments were performed to determine the effect of exosomal PTENP1.

Results

PTENP1 was significantly reduced in BC tissues and in exosomes from plasma of patients with BC (P?ConclusionExosomal PTENP1 is a promising novel biomarker that can be used for the clinical detection of BC. Exosomes derived from normal cells transfer PTENP1 to BC cells, which reduce the progression of BC both in vitro and in vivo and suggest that exosomal PTENP1 participates in normal-cell-to-bladder-cell communication during the carcinogenesis of BC.

SUBMITTER: Zheng R 

PROVIDER: S-EPMC6169076 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature