Dataset Information

Five-Year Predictors of Insulin Initiation in People with Type 2 Diabetes under Real-Life Conditions.

ABSTRACT: We performed a real-life analysis of clinical and laboratory parameters, in orally treated T2DM patients aiming at identifying predictors of insulin treatment initiation. Overall, 366955 patients (55.8% males, age 65?±?11 years, diabetes duration 7?±?8 years) were followed up between 2004 and 2011. Each patient was analyzed step-by-step until either eventually starting insulin treatment or getting to the end of the follow-up period. Patients switching to insulin showed a worse global risk profile, longer disease duration (10?±?9 years vs. 6?±?7 years, respectively; p < 0.001), higher HbA1c (8.0?±?1.6% vs. 7.2?±?1.5%, respectively; p < 0.001), higher triglycerides, a greater prevalence of arterial hypertension, antihypertensive, lipid-lowering and aspirin treatment, a higher rate of nonproliferative/proliferative retinopathy, and a nearly 4 times lower prevalence of the "diet alone." They also showed a higher prevalence of subjects with eGFR?

SUBMITTER: Gentile S

PROVIDER: S-EPMC6169213 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Five-Year Predictors of Insulin Initiation in People with Type 2 Diabetes under Real-Life Conditions.

Gentile Sandro S Strollo Felice F Viazzi Francesca F Russo Giuseppina G Piscitelli Pamela P Ceriello Antonio A Giorda Carlo C Guida Piero P Fioretto Paola P Pontremoli Roberto R De Cosmo Salvatore S The Amd-Annals Study Group

Journal of diabetes research 20180919

We performed a real-life analysis of clinical and laboratory parameters, in orally treated T2DM patients aiming at identifying predictors of insulin treatment initiation. Overall, 366955 patients (55.8% males, age 65 ± 11 years, diabetes duration 7 ± 8 years) were followed up between 2004 and 2011. Each patient was analyzed step-by-step until either eventually starting insulin treatment or getting to the end of the follow-up period. Patients switching to insulin showed a worse global risk profil ...[more]

PMID: 30327785

Similar Datasets

Project description:Aquatic fireflies are important indicators of the quality of freshwater environments and key models for research on insect adaptation to freshwater environments. For these investigations, gene expression analyses using quantitative real-time PCR are heavily dependent on reliable reference genes. In this study, based on a transcriptome assembly and annotation for the aquatic firefly Aquatica leii at the adult and larval stages, 10 candidate reference genes (?-tubulin, ?-tubulin, ?-actin, EF1A, SDHA, UBQ, GST, GAPDH, RPS31, and RPL13A) were identified for analyses of expression stability. Quantitative real-time PCR analyses for each candidate reference genes in A. leii was conducted for four developmental stages, four adult tissue types, two adult sexes, and two ecological stressors [adults exposed to five temperatures and larvae exposed to four concentrations of benzo(a)pyrene]. Results were evaluated by three independent algorithms (geNorm, NormFinder, and BestKeeper) and one comparative algorithm (RefFinder). The expression stability of candidate reference genes in A. leii differed under various conditions. Reference genes with the most stable expressions levels in different tissues, temperatures, sexes, developmental stages, and concentrations of benzo(a)pyrene were ?-tubulin, GST, ?-actin, ?-tubulin, and ?-tubulin, respectively. Furthermore, the optimal normalization factors (NFs) for the quantification of the expression levels of target genes by quantitative real-time PCR analyses of A. leii were identified for each experimental group. In particular, NF = 2 for different tissues (?-tubulin + ?-tubulin), different sexes (?-actin + EF1A), and larvae exposed to different concentrations of benzo(a)pyrene (?-tubulin + EF1A); NF = 3 for developmental stages (GST + GAPDH + SDHA) and adults exposed to different temperatures (?-tubulin + EFA + GST). In addition, we surveyed the expression profiles of two target genes (CYP3A and CSP8) in larvae exposed to different concentrations of benzo(a)pyrene and in different adult tissues. The results further validated the reliability of the reference genes. The optimal reference genes for various experimental conditions identified in these analyses provide a useful tool for ecological studies of aquatic fireflies.

Dataset Information

Five-Year Predictors of Insulin Initiation in People with Type 2 Diabetes under Real-Life Conditions.

Publications

Five-Year Predictors of Insulin Initiation in People with Type 2 Diabetes under Real-Life Conditions.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets