Ontology highlight
ABSTRACT:
SUBMITTER: Boele HJ
PROVIDER: S-EPMC6170036 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Boele Henk-Jan HJ Peter Saša S Ten Brinke Michiel M MM Verdonschot Lucas L IJpelaar Anna C H ACH Rizopoulos Dimitris D Gao Zhenyu Z Koekkoek Sebastiaan K E SKE De Zeeuw Chris I CI
Science advances 20181003 10
Pavlovian eyeblink conditioning has been used extensively to study the neural mechanisms underlying associative and motor learning. During this simple learning task, memory formation takes place at Purkinje cells in defined areas of the cerebellar cortex, which acquire a strong temporary suppression of their activity during conditioning. Yet, it is unknown which neuronal plasticity mechanisms mediate this suppression. Two potential mechanisms include long-term depression of parallel fiber to Pur ...[more]