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Impact of parallel fiber to Purkinje cell long-term depression is unmasked in absence of inhibitory input.


ABSTRACT: Pavlovian eyeblink conditioning has been used extensively to study the neural mechanisms underlying associative and motor learning. During this simple learning task, memory formation takes place at Purkinje cells in defined areas of the cerebellar cortex, which acquire a strong temporary suppression of their activity during conditioning. Yet, it is unknown which neuronal plasticity mechanisms mediate this suppression. Two potential mechanisms include long-term depression of parallel fiber to Purkinje cell synapses and feed-forward inhibition by molecular layer interneurons. We show, using a triple transgenic approach, that only concurrent disruption of both these suppression mechanisms can severely impair conditioning, highlighting that both processes can compensate for each other's deficits.

SUBMITTER: Boele HJ 

PROVIDER: S-EPMC6170036 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Impact of parallel fiber to Purkinje cell long-term depression is unmasked in absence of inhibitory input.

Boele Henk-Jan HJ   Peter Saša S   Ten Brinke Michiel M MM   Verdonschot Lucas L   IJpelaar Anna C H ACH   Rizopoulos Dimitris D   Gao Zhenyu Z   Koekkoek Sebastiaan K E SKE   De Zeeuw Chris I CI  

Science advances 20181003 10


Pavlovian eyeblink conditioning has been used extensively to study the neural mechanisms underlying associative and motor learning. During this simple learning task, memory formation takes place at Purkinje cells in defined areas of the cerebellar cortex, which acquire a strong temporary suppression of their activity during conditioning. Yet, it is unknown which neuronal plasticity mechanisms mediate this suppression. Two potential mechanisms include long-term depression of parallel fiber to Pur  ...[more]

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