Functional brain connectivity is predictable from anatomic network's Laplacian eigen-structure.

ABSTRACT: How structural connectivity (SC) gives rise to functional connectivity (FC) is not fully understood. Here we mathematically derive a simple relationship between SC measured from diffusion tensor imaging, and FC from resting state fMRI. We establish that SC and FC are related via (structural) Laplacian spectra, whereby FC and SC share eigenvectors and their eigenvalues are exponentially related. This gives, for the first time, a simple and analytical relationship between the graph spectra of structural and functional networks. Laplacian eigenvectors are shown to be good predictors of functional eigenvectors and networks based on independent component analysis of functional time series. A small number of Laplacian eigenmodes are shown to be sufficient to reconstruct FC matrices, serving as b

SUBMITTER: Abdelnour F 

PROVIDER: S-EPMC6170160 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature