Ontology highlight
ABSTRACT:
SUBMITTER: Tanaka S
PROVIDER: S-EPMC6170178 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Tanaka Shigeru S Suto Akira A Iwamoto Taro T Kageyama Takahiro T Tamachi Tomohiro T Takatori Hiroaki H Suzuki Kotaro K Hirose Koichi K Ohara Osamu O Lefebvre Véronique V Nakajima Hiroshi H
The Journal of experimental medicine 20180906 10
Peripherally induced regulatory T (pT reg) cells play indispensable roles in regulating gut inflammation; however, the mechanism underling the differentiation of pT reg cells under inflammatory conditions remains largely unknown. Here, we show that the expression of Sox12, a member of SoxC family, is significantly induced in T reg cells in colitic mice. We also show that TCR-NFAT signaling induces Sox12 expression in CD4<sup>+</sup> T cells. Although Sox12 is not required for the development of ...[more]