Ontology highlight
ABSTRACT:
SUBMITTER: Rogers TD
PROVIDER: S-EPMC6170422 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Rogers Troy D TD Ostrowski Lawrence E LE Livraghi-Butrico Alessandra A Button Brian B Grubb Barbara R BR
Scientific reports 20181003 1
Mucociliary clearance (MCC) is the first line of defense in clearing airways. In genetically engineered mice, each component of this system (ciliary beat, mucus, airway surface hydration) can be studied separately to determine its contribution to MCC. Because MCC is difficult to measure in mice, MCC measurements are often omitted from these studies. We report a simple method to measure MCC in mice involving nasal inhalation of aerosolized fluorescent beads and trans-tracheal bead tracking. This ...[more]