Ontology highlight
ABSTRACT:
SUBMITTER: Yoon S
PROVIDER: S-EPMC6171260 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Yoon Sangtae S Kang Kyojin K Cho Young-Duck YD Kim Yohan Y Buisson Elina Maria EM Yim Ji-Hye JH Lee Seung Bum SB Ryu Ki-Young KY Jeong Jaemin J Choi Dongho D
BioMed research international 20180920
Recently, several researchers have reported that direct reprogramming techniques can be used to differentiate fibroblasts into hepatocyte-like cells without a pluripotent intermediate step. However, the use of viral vectors for conversion continues to pose important challenges in terms of genome integration. Herein, we propose a new method of direct conversion without genome integration with potential clinical applications. To generate hepatocyte-like cells, mRNA coding for the hepatic transcrip ...[more]