Ontology highlight
ABSTRACT:
SUBMITTER: Sung JA
PROVIDER: S-EPMC6171327 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Sung Julia A JA Patel Shabnum S Clohosey Matthew L ML Roesch Lauren L Tripic Tamara T Kuruc JoAnn D JD Archin Nancie N Hanley Patrick J PJ Cruz C Russell CR Goonetilleke Nilu N Eron Joseph J JJ Rooney Clio M CM Gay Cynthia L CL Bollard Catherine M CM Margolis David M DM
Molecular therapy : the journal of the American Society of Gene Therapy 20180921 10
Adoptive T cell therapy has had dramatic successes in the treatment of virus-related malignancies and infections following hematopoietic stem cell transplantation. We adapted this method to produce ex vivo expanded HIV-specific T cells (HXTCs), with the long-term goal of using HXTCs as part of strategies to clear persistent HIV infection. In this phase 1 proof-of-concept study (NCT02208167), we administered HXTCs to antiretroviral therapy (ART)-suppressed, HIV-infected participants. Participants ...[more]