Ontology highlight
ABSTRACT:
SUBMITTER: Coia H
PROVIDER: S-EPMC6171362 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Coia Heidi H Ma Ning N Hou Yanqi Y Dyba Marcin D MD Fu Ying Y Cruz M Idalia MI Benitez Carlos C Graham Garrett T GT McCutcheon Justine N JN Zheng Yun-Ling YL Sun Bing B Kallakury Bhaskar V BV Ma Junfeng J Fang Hong-Bin HB Berry Deborah L DL Muralidaran Vinona V Chung Fung-Lung FL
Cancer prevention research (Philadelphia, Pa.) 20180821 10
Obesity is associated with cancer risk and its link with liver cancer is particularly strong. Obesity causes non-alcoholic fatty liver disease (NAFLD) that could progress to hepatocellular carcinoma (HCC). Chronic inflammation likely plays a key role. We carried out a bioassay in the high-fat diet (HFD)-fed C57BL/6J mice to provide insight into the mechanisms of obesity-related HCC by studying γ-OHPdG, a mutagenic DNA adduct derived from lipid peroxidation. In an 80-week bioassay, mice received ...[more]