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The microRNA-127-3p directly targeting Vamp2 in C2C12 myoblasts.

ABSTRACT: MicroRNAs (miRNAs) have been reported that can regulate skeletal muscle growth and development. Previously, we demonstrated that miR-127-3p were differently expressed in skeletal muscle and muscle cells. However, the molecular mechanism of miR-127-3p regulation of skeletal myogenesis are not well elucidated. In this study, we transfected miR-127-3p into C2C12 cells, and found miR-127-3p induces myogenesis by targeting Vamp2. Moreover, the regulatory mechanism of Vamp2 in myoblasts proliferation and differentiation was further confirmed. In conclusion, our data providedevidences that miR-127-3p reciprocally regulated myoblasts proliferation and differentiation through directly targeting Vamp2.

SUBMITTER: Li J

PROVIDER: S-EPMC6171451 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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The microRNA-127-3p directly targeting Vamp2 in C2C12 myoblasts.

Li Jie J Wang Gaofu G Jiang Jing J Fu Lin L Zhou Peng P Ren Hangxing H

Animal cells and systems 20180825 5

MicroRNAs (miRNAs) have been reported that can regulate skeletal muscle growth and development. Previously, we demonstrated that miR-127-3p were differently expressed in skeletal muscle and muscle cells. However, the molecular mechanism of miR-127-3p regulation of skeletal myogenesis are not well elucidated. In this study, we transfected miR-127-3p into C2C12 cells, and found miR-127-3p induces myogenesis by targeting Vamp2. Moreover, the regulatory mechanism of Vamp2 in myoblasts ...[more]

PMID: 30460111

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