Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC6171490 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Wang Xuefeng X Chen Hao H Zhang Nancy R NR
Briefings in bioinformatics 20180901 5
Currently, there is a lack of software for detecting copy number variations and constructing copy number profile for the whole genome from single-cell DNA sequencing data, which are often of low coverage and high technical noises. Here we introduce a new toolkit, SCNV, which features an efficient bin-free segmentation approach and provides the highest resolution possible for breakpoint detection and the subsequent copy number calling. SCNV can auto-tune parameters based on a set of normal cells ...[more]