Ontology highlight
ABSTRACT:
SUBMITTER: Fukusumi T
PROVIDER: S-EPMC6171749 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Fukusumi Takahito T Guo Theresa W TW Sakai Akihiro A Ando Mizuo M Ren Shuling S Haft Sunny S Liu Chao C Amornphimoltham Panomwat P Gutkind J Silvio JS Califano Joseph A JA
Clinical cancer research : an official journal of the American Association for Cancer Research 20171116 3
<b>Purpose:</b> Recently, several comprehensive genomic analyses demonstrated <i>NOTCH1</i> and <i>NOTCH3</i> mutations in head and neck squamous cell carcinoma (HNSCC) in approximately 20% of cases. Similar to other types of cancers, these studies also indicate that the <i>NOTCH</i> pathway is closely related to HNSCC progression. However, the role of <i>NOTCH4</i> in HNSCC is less well understood.<b>Experimental Design:</b> We analyzed <i>NOTCH4</i> pathway and downstream gene expression in th ...[more]