Ontology highlight
ABSTRACT:
SUBMITTER: Castelli G
PROVIDER: S-EPMC6172000 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
International journal of hematologic oncology 20161201 4
The rapid advancement of next-generation sequencing techniques and the identification of molecular driver events responsible for leukemia development are opening the door to new pharmacologic-targeted agents to tailor treatment of acute myeloid leukemia (AML) in individual patients. However, the use of targeted therapies in AML has met with only modest success. Molecular studies have identified AML subsets characterized by driver mutational events, such as <i>NPM1, FLT3-ITD</i> and <i>IDH1-2</i> ...[more]