Altered editing level of microRNAs is a potential biomarker in lung adenocarcinoma.
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ABSTRACT:
SUBMITTER: Maemura K
PROVIDER: S-EPMC6172074 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Altered editing level of microRNAs is a potential biomarker in lung adenocarcinoma.
Maemura Keita K Watanabe Kousuke K Ando Takahiro T Hiyama Noriko N Sakatani Toshio T Amano Yosuke Y Kage Hidenori H Nakajima Jun J Yatomi Yutaka Y Nagase Takahide T Takai Daiya D
Cancer science 20180906 10
Adenosine-to-inosine (A-to-I) microRNA editing is associated with tumor phenotypes in various cancer types. Recent analyses of The Cancer Genome Atlas (TCGA) dataset have shown several microRNAs that undergo A-to-I editing in human cancers, some of which have been reported to be associated with prognosis. Herein, we examined published small RNA deep sequencing data of 74 cases of lung adenocarcinoma (AD) and the corresponding normal counterpart (NC) specimen in silico in order to identify A-to-I ...[more]
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