Ontology highlight
ABSTRACT:
SUBMITTER: Martin KR
PROVIDER: S-EPMC6172447 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Martin Katie R KR Celano Stephanie L SL Solitro Abigail R AR Gunaydin Hakan H Scott Mark M O'Hagan Ronan C RC Shumway Stuart D SD Fuller Peter P MacKeigan Jeffrey P JP
iScience 20180919
In response to stress, cancer cells generate nutrients and energy through a cellular recycling process called autophagy, which can promote survival and tumor progression. Accordingly, autophagy inhibition has emerged as a potential cancer treatment strategy. Inhibitors targeting ULK1, an essential and early autophagy regulator, have provided proof of concept for targeting this kinase to inhibit autophagy; however, these are limited individually in their potency, selectivity, or cellular activity ...[more]