Ontology highlight
ABSTRACT:
SUBMITTER: Tie CH
PROVIDER: S-EPMC6172469 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Tie Christopher Hc CH Fernandes Liane L Conde Lucia L Robbez-Masson Luisa L Sumner Rebecca P RP Peacock Tom T Rodriguez-Plata Maria Teresa MT Mickute Greta G Gifford Robert R Towers Greg J GJ Herrero Javier J Rowe Helen M HM
EMBO reports 20180730 10
Endogenous retroviruses (ERVs) have accumulated in vertebrate genomes and contribute to the complexity of gene regulation. KAP1 represses ERVs during development by its recruitment to their repetitive sequences through KRAB zinc-finger proteins (KZNFs), but little is known about the regulation of ERVs in adult tissues. We observed that KAP1 repression of HERVK14C was conserved in differentiated human cells and performed KAP1 knockout to obtain an overview of KAP1 function. Our results show that ...[more]