Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC6172609 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Zhang Xiaoling X Frame Alissa A AA Williams Jonathan S JS Wainford Richard D RD
Physiological genomics 20180615 9
Salt sensitivity of blood pressure (BP) increases hypertension risk and associated adverse cardiovascular outcomes. At present, there are no validated rapid tests or diagnostic markers to identify salt sensitivity of BP in clinical practice. Based on our prior animal studies that report a role for brain Gαi<sub>2</sub> proteins in the salt sensitivity of BP and evidence that GNAI2 single nucleotide polymorphisms (SNPs) associate with hypertension risk, we investigated the hypothesis that GNAI2 S ...[more]