Ontology highlight
ABSTRACT:
SUBMITTER: Podolsky MJ
PROVIDER: S-EPMC6172619 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Podolsky Michael J MJ Gupta Deepti D Ha Arnold A Ta Ryan R Khalifeh-Soltani Amin A McKleroy William W Datta Ritwik R Sheppard Dean D Atabai Kamran K
American journal of physiology. Lung cellular and molecular physiology 20180524 3
Although extensive work has delineated many of the mechanisms of extracellular matrix (ECM) production, far less is known about pathways that regulate ECM degradation. This is particularly true of cellular internalization and degradation of matrix, which play an underappreciated role in ECM metabolism and lung fibrosis. For example, genetic perturbation of this pathway leads to exacerbated fibrosis in experimental animal models. In this work, we present the results of an unbiased screen of Droso ...[more]