Dataset Information
Impact of PCSK9 monoclonal antibodies on circulating hs-CRP levels: a systematic review and meta-analysis of randomised controlled trials.
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ABSTRACT: Objective
To evaluate the potential effects of proprotein convertase subtilisin/kexin type 9 monoclonal antibody (PCSK9-mAb) on high-sensitivity C reactive protein (hs-CRP) concentrations.Design
A systematic review and meta-analysis of randomised controlled trials.Data sources
PubMed, MEDLINE, the Cochrane Library databases, ClinicalTrials.gov and recent conferences were searched from inception to May 2018.Eligibility criteria for selecting studies
All randomised controlled trials that reported changes of hs-CRP were included.Results
Ten studies involving 4198 participants were identified. PCSK9-mAbs showed a slight efficacy in reducing hs-CRP (-0.04?mg/L, 95%?CI: -0.17 to 0.01) which was not statistically different. The results did not altered when subgroup analyses were performed including PCSK9-mAb types (alirocumab: 0.12?mg/L, 95%?CI: -0.18 to 0.43; evolocumab: 0.00?mg/L, 95%?CI: -0.07 to 0.07; LY3015014: -0.48?mg/L, 95%?CI: -1.28 to 0.32; RG7652: 0.35?mg/L, 95%?CI: -0.26 to 0.96), treatment duration (?12w: 0.00?mg/L, 95%?CI: -0.07 to 0.07; >12w: -0.11?mg/L, 95%?CI: -0.45 to -0.23), participant characteristics (familial hypercholesterolaemia: 0.00?mg/L, 95%?CI: -0.07 to 0.07; non-familial hypercholesterolaemia: 0.07?mg/L, 95%?CI: -0.12 to 0.26; mix: -0.48?mg/L, 95%?CI: -1.28 to 0.32) and treatment methods (monotherapy: 0.00?mg/L, -0.08 to 0.07; combination therapy: -0.08?mg/L, -0.37 to 0.21). Meta-regression analyses suggested no significant linear correlation between baseline age (p=0.673), sex (p=0.645) and low-density lipoprotein cholesterol reduction (p=0.339).Conclusions
Our updated meta-analysis suggested that PCSK9-mAbs had no significant impact on circulating hs-CRP levels irrespective of PCSK9-mAb types, participant characteristics and treatment duration or methods.
SUBMITTER: Cao YX
PROVIDER: S-EPMC6173233 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Impact of PCSK9 monoclonal antibodies on circulating hs-CRP levels: a systematic review and meta-analysis of randomised controlled trials.
BMJ open 20181004 9
<h4>Objective</h4>To evaluate the potential effects of proprotein convertase subtilisin/kexin type 9 monoclonal antibody (PCSK9-mAb) on high-sensitivity C reactive protein (hs-CRP) concentrations.<h4>Design</h4>A systematic review and meta-analysis of randomised controlled trials.<h4>Data sources</h4>PubMed, MEDLINE, the Cochrane Library databases, ClinicalTrials.gov and recent conferences were searched from inception to May 2018.<h4>Eligibility criteria for selecting studies</h4>All randomised ...[more]