Ontology highlight
ABSTRACT:
SUBMITTER: Bosak A
PROVIDER: S-EPMC6173406 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Bosak Anita A Ramić Alma A Šmidlehner Tamara T Hrenar Tomica T Primožič Ines I Kovarik Zrinka Z
PloS one 20181005 10
This paper describes the synthesis and anticholinesterase potency of Cinchona-based alkaloids; ten quaternary derivatives of cinchonines and their corresponding pseudo-enantiomeric cinchonidines. The quaternization of quinuclidine moiety of each compound was carried out with groups diverse in their size: methyl, benzyl and differently meta- and para-substituted benzyl groups. All of the prepared compounds reversibly inhibited human butyrylcholinesterase and acetylcholinesterase with Ki constants ...[more]