Ontology highlight
ABSTRACT:
SUBMITTER: Okazaki S
PROVIDER: S-EPMC6173468 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Okazaki Shogo S Shintani Subaru S Hirata Yuki Y Suina Kentaro K Semba Takashi T Yamasaki Juntaro J Umene Kiyoko K Ishikawa Miyuki M Saya Hideyuki H Nagano Osamu O
Oncotarget 20180918 73
The cystine-glutamate antiporter subunit xCT suppresses iron-dependent oxidative cell death (ferroptosis) and is therefore a promising target for cancer treatment. Given that cancer cells often show resistance to xCT inhibition resulting in glutathione (GSH) deficiency, however, we here performed a synthetic lethal screen of a drug library to identify agents that sensitize the GSH deficiency-resistant cancer cells to the xCT inhibitor sulfasalazine. This screen identified the oral anesthetic dyc ...[more]