Ontology highlight
ABSTRACT:
SUBMITTER: Sassi M
PROVIDER: S-EPMC6173571 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Sassi Monica M Kutty Geetha G Ferreyra Gabriela A GA Bishop Lisa R LR Liu Yueqin Y Qiu Ju J Huang Da Wei DW Kovacs Joseph A JA
The Journal of infectious diseases 20181001 10
The major surface glycoprotein (Msg) is the most abundant surface protein among Pneumocystis species. Given that Msg is present on both the cyst and trophic forms of Pneumocystis and that dendritic cells play a critical role in initiating host immune responses, we undertook studies to examine activation of bone marrow-derived myeloid dendritic cells by Msg purified from Pneumocystis murina. Incubation of dendritic cells with Msg did not lead to increased expression of CD40, CD80, CD86, or major ...[more]